The DLC1 Polyclonal Antibody (CAB1921) is a valuable tool for researchers studying the DLC1 protein, a tumor suppressor implicated in the regulation of cell adhesion, migration, and invasion. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blotting. By targeting the DLC1 protein, this antibody facilitates the detection and analysis of DLC1 expression in different cell types, providing insights into its role in cancer biology and metastasis.DLC1, also known as Deleted in Liver Cancer 1, functions as a RhoGAP protein that modulates Rho GTPase signaling and regulates actin cytoskeleton dynamics, thereby influencing cellular processes such as cell migration and invasion.
Dysregulation of DLC1 expression has been associated with various types of cancer, including liver cancer, breast cancer, and prostate cancer, highlighting its importance as a potential therapeutic target. Research on DLC1 holds promise for developing novel treatment strategies aimed at inhibiting cancer progression and metastasis by restoring DLC1 function or targeting its downstream signaling pathways.
Product Name:
DLC1 Rabbit Polyclonal Antibody
SKU:
CAB1921
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 204-463 of human DLC1 (NP_079043.3).
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using DLC1 antibody (CAB1921) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).
