DLAT Rabbit Polyclonal Antibody (CAB6288)
- SKU:
- CAB6288
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | DLAT Rabbit Polyclonal Antibody |
SKU: | CAB6288 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DLAT (NP_001922.2). |
Sequence: | MWRV CARR AQNV APWA GLEA RWTA LQEV PGTP RVTS RSGP APAR RNSV TTGY GGVR ALCG WTPS SGAT PRNR LLLQ LLGS PGRR YYSL PPHQ KVPL PSLS PTMQ AGTI ARWE KKEG DKIN EGDL IAEV ETDK ATVG FESL EECY MAKI LVAE GTRD VPIG AIIC ITVG KPED IEAF KNYT LDSS AAPT PQAA PAPT PAAT ASPP TPSA QAPG SSYP PHMQ VLLP ALSP TMTM GTVQ RWEK KVGE KLSE GDLL AEIE TDKA TIGF EVQE EGYL AKIL VPEG TRDV PLGT PL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:20 - 1:50 |
Synonyms: | E2; PBC; DLTA; PDCE2; PDC-E2; DLAT |
Positive Sample: | SW620,22Rv1,U-251MG,HepG2,Jurkat,293T,Rat brain,Rat kidney,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 69kDa |
Observed MW: | 69kDa |
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Purification Method: | Affinity purification |
Gene ID: | 1737 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |