The DKK3 Polyclonal Antibody (CAB17139) is a valuable tool for researchers studying DKK3, a secreted protein involved in various cellular processes such as cell proliferation, differentiation, and apoptosis. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to DKK3, this antibody enables the detection and analysis of the protein in a variety of cell types, making it ideal for studies in developmental biology, cancer research, and regenerative medicine.DKK3, a member of the Dickkopf family of proteins, is known for its role in regulating the Wnt signaling pathway, which plays a critical role in embryonic development and tissue homeostasis.
Dysregulation of DKK3 has been implicated in various diseases, including cancer, osteoporosis, and cardiovascular disorders. Understanding the function of DKK3 and its interaction with the Wnt pathway is essential for developing targeted therapies and diagnostic tools for these conditions.Overall, the DKK3 Polyclonal Antibody (CAB17139) offers researchers a reliable means of studying DKK3 expression and function, thereby advancing our understanding of its role in health and disease.
Product Name:
DKK3 Rabbit Polyclonal Antibody
SKU:
CAB17139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-200 of human DKK3 (NP_056965.3).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
27122
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DKK3 Rabbit pAb (CAB17139) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
