The DKK2 Polyclonal Antibody (CAB14874) is an essential tool for researchers studying the role of DKK2 in various biological processes. DKK2, a member of the Dickkopf family of proteins, is known for its involvement in the Wnt signaling pathway, which plays a crucial role in embryonic development, cell proliferation, and differentiation.This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the DKK2 protein, researchers can accurately detect and analyze its expression in different cell types, paving the way for insights into its functions in development, tissue homeostasis, and disease pathways.
DKK2 has been linked to various diseases, including cancer, osteoporosis, and Alzheimer's disease, highlighting its importance as a potential therapeutic target. By elucidating the molecular mechanisms underlying DKK2's actions, researchers can potentially uncover new treatment strategies for these conditions. The DKK2 Polyclonal Antibody is a valuable tool for advancing our understanding of DKK2 biology and its implications for human health.
Product Name:
DKK2 Rabbit Polyclonal Antibody
SKU:
CAB14874
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human DKK2 (NP_055236.1).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
Purification Method:
Affinity purification
Gene ID:
27123
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DKK2 Rabbit pAb (CAB14874) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
