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DKK1 Rabbit Polyclonal Antibody (CAB2562)

SKU:
CAB2562
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

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Product Name:DKK1 Rabbit Polyclonal Antibody
SKU:CAB2562
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-266 of human DKK1 (NP_036374.1).
Sequence:TLNS VLNS NAIK NLPP PLGG AAGH PGSA VSAA PGIL YPGG NKYQ TIDN YQPY PCAE DEEC GTDE YCAS PTRG GDAG VQIC LACR KRRK RCMR HAMC CPGN YCKN GICV SSDQ NHFR GEIE ETIT ESFG NDHS TLDG YSRR TTLS SKMY HTKG QEGS VCLR SSDC ASGL CCAR HFWS KICK PVLK EGQV CTKH RRKG SHGL EIFQ RCYC GEGL SCRI QKDH HQAS NSSR LHTC QRH
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:SK; DKK-1; DKK1
Positive Sample:HeLa,K-562,Mouse brain,Rat brain,Rat liver
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:29kDa
Observed MW:28-45kDa

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.

Purification Method:Affinity purification
Gene ID:22943
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using DKK1 Rabbit pAb (CAB2562) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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