The DKC1 Rabbit Monoclonal Antibody (CAB4407) is a powerful tool for researchers studying DKC1, a protein essential for telomere maintenance and ribosomal RNA processing. This antibody, produced in rabbits, is highly specific for DKC1 and has been validated for use in various applications, including Western blot and immunohistochemistry.DKC1 is a multifunctional protein that plays a critical role in cell growth and division, making it a key target for investigation in cancer and other diseases. Dysregulation of DKC1 has been implicated in various cancers, making this antibody valuable for studies aiming to understand the molecular mechanisms underlying these diseases.
By using the DKC1 Rabbit Monoclonal Antibody (CAB4407), researchers can accurately detect and analyze DKC1 protein expression in different cell types and tissues, advancing our understanding of its role in cellular processes. This antibody is a valuable tool for research in oncology, molecular biology, and cell biology, offering new insights into the functions of DKC1 and its potential as a therapeutic target in cancer treatment.
Product Name:
DKC1 Rabbit Monoclonal Antibody
SKU:
CAB4407
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human DKC1 (O60832).
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1736
Clone Number:
ARC1063
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from PC-3 cells, using DKC1 Rabbit mAb (CAB4407) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
