The DKC1 Polyclonal Antibody (CAB12914) is a valuable tool for research involving DKC1, a protein involved in telomere maintenance and ribosomal RNA processing. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.DKC1, also known as dyskerin, plays a crucial role in maintaining telomere length and integrity, which is essential for cell survival and proliferation. Additionally, DKC1 is involved in ribosomal RNA processing, impacting protein synthesis within the cell.
Dysregulation of DKC1 has been linked to various diseases, including dyskeratosis congenita and cancer.By utilizing the DKC1 Polyclonal Antibody, researchers can study the expression and localization of DKC1 in different cell types and tissues, providing valuable insights into its function and potential role in disease development. This antibody is a valuable tool for advancing research in telomere biology, ribosome biogenesis, and the molecular mechanisms underlying various diseases.
Product Name:
DKC1 Rabbit Polyclonal Antibody
SKU:
CAB12914
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human DKC1 (NP_001354.1).
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1736
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DKC1 Rabbit pAb (CAB12914) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
