DKC1 Rabbit Polyclonal Antibody (CAB12914)
- SKU:
- CAB12914
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DKC1 Rabbit Polyclonal Antibody |
SKU: | CAB12914 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human DKC1 (NP_001354.1). |
Sequence: | MADA EVII LPKK HKKK KERK SLPE EDVA EIQH AEEF LIKP ESKV AKLD TSQW PLLL KNFD KLNV RTTH YTPL ACGS NPLK REIG DYIR TGFI NLDK PSNP SSHE VVAW IRRI LRVE KTGH SGTL DPKV TGCL IVCI ERAT RLVK SQQS AGKE YVGI VRLH NAIE GGTQ LSRA LETL TGAL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | DKC; CBF5; DKCX; NAP57; NOLA4; XAP101; DKC1 |
Positive Sample: | HeLa,22Rv1,HepG2,MCF7,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cajal body, Cytoplasm, Nucleus, nucleolus. |
Calculated MW: | 58kDa |
Observed MW: | 57kDa |
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1736 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |