The DISP1 Polyclonal Antibody (CAB14946) is a valuable tool for research involving the DISP1 protein, a key component in the Hedgehog signaling pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.The DISP1 protein is essential for embryonic development and plays a crucial role in regulating cell differentiation and proliferation. Dysregulation of the Hedgehog pathway, in which DISP1 is a critical player, has been implicated in various developmental disorders and cancers.
As such, studying DISP1 with this specific antibody can provide insights into its function and potential therapeutic applications in these disease contexts.Researchers in developmental biology, cancer biology, and regenerative medicine will find the DISP1 Polyclonal Antibody to be a valuable tool for investigating the intricate mechanisms of the Hedgehog signaling pathway and its implications in disease progression. Its specificity and reliability make it an ideal choice for studying DISP1 expression and localization in various experimental settings.
Product Name:
DISP1 Rabbit Polyclonal Antibody
SKU:
CAB14946
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1325-1524 of human DISP1 (NP_116279.2).
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.
Purification Method:
Affinity purification
Gene ID:
84976
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DISP1 Rabbit pAb (CAB14946) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
