Disintegrin EC3B Antibody (PACO34024)
- SKU:
- PACO34024
- Product Type:
- Antibody
- Reactivity:
- Snake
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Disintegrin EC3B Antibody (PACO34024) |
| Antibody SKU: | PACO34024 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Echis carinatus |
| Immunogen: | Recombinant Echis carinatus Disintegrin EC3B protein (1-67AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B. |
| Synonyms: | Disintegrin EC3B |
| UniProt Protein Function: | Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P81631 |
| NCBI GenInfo Identifier: | 6014971 |
| NCBI Gene ID: | |
| NCBI Accession: | P81631.1 |
| UniProt Secondary Accession: | P81631 |
| UniProt Related Accession: | P81631 |
| Molecular Weight: | 7,424 Da |
| NCBI Full Name: | Disintegrin EC3B |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Disintegrin EC3B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Disintegrin |
| UniProt Gene Name: | |
| UniProt Entry Name: |