The Disintegrin EC3B Antibody (PACO34024) is a polyclonal antibody designed for research involving the disintegrin EC3B protein. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blotting. By binding to the disintegrin EC3B protein, this antibody enables accurate detection and analysis in different cell types, making it an ideal tool for studies in immunology and cancer research.The disintegrin EC3B protein is known for its role in cell adhesion and migration, making it a crucial player in various physiological and pathological processes.
Understanding the function and regulation of the disintegrin EC3B protein is essential for unraveling its implications in diseases like cancer, cardiovascular disorders, and inflammatory conditions. This antibody provides researchers with a valuable tool to investigate the mechanisms involving the disintegrin EC3B protein and its potential as a therapeutic target in various disease contexts.
Antibody Name:
Disintegrin EC3B Antibody (PACO34024)
Antibody SKU:
PACO34024
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Echis carinatus
Immunogen:
Recombinant Echis carinatus Disintegrin EC3B protein (1-67AA)
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B.
Synonyms:
Disintegrin EC3B
UniProt Protein Function:
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B.
