The DISC1 Polyclonal Antibody (CAB2898) is a vital tool for researchers studying the role of DISC1, a protein closely associated with psychiatric disorders such as schizophrenia and bipolar disorder. Raised in rabbits, this antibody shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the DISC1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential resource for investigations into mental health and neurological disorders.
DISC1, or Disrupted in Schizophrenia 1, is a key player in neuronal development and function, with its dysfunction linked to various psychiatric conditions. Research into DISC1's mechanisms can provide crucial insights into the pathophysiology of these disorders and potentially lead to the development of novel therapeutic strategies. The DISC1 Polyclonal Antibody is a valuable asset for scientists seeking to unravel the mysteries of psychiatric illness and pave the way for new treatments in the future.
Product Name:
DISC1 Rabbit Polyclonal Antibody
SKU:
CAB2898
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DISC1 (NP_001158009.1).
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
27185
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DISC1 antibody (CAB2898) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
