The Disabled Homolog 1 Polyclonal Antibody (CAB10349) is a powerful tool for researchers studying the Disabled Homolog 1 protein, known for its involvement in various cellular processes including cell signaling and receptor internalization. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards Disabled Homolog 1 in human samples, making it suitable for use in Western blotting and immunohistochemistry applications.Disabled Homolog 1, also referred to as DAB1, is a key player in neuronal development and synaptic plasticity, making it a compelling target for neuroscience and neurodevelopmental research.
Dysfunction of DAB1 has been associated with neurodevelopmental disorders such as autism and schizophrenia, underscoring the importance of studying its function and regulation.By utilizing the Disabled Homolog 1 Polyclonal Antibody, researchers can gain valuable insights into the role of DAB1 in various biological processes and disease states, paving the way for potential therapeutic interventions targeting this protein. Its versatility and reliability make it an essential tool for investigations into the molecular mechanisms underlying neurodevelopmental disorders and synaptic plasticity.
Product Name:
DAB1 Rabbit Polyclonal Antibody
SKU:
CAB10349
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DAB1 (NP_066566.3).
cytoplasm, cytosol, perinuclear region of cytoplasm
Calculated MW:
64kDa
Observed MW:
57kDa/59kDa
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.
Purification Method:
Affinity purification
Gene ID:
1600
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DAB1 antibody (CAB10349) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
