The DIS3 Polyclonal Antibody (CAB8027) is essential for research related to the DIS3 protein, a key component of the RNA exosome complex involved in RNA processing and degradation. This antibody is produced in rabbits and is highly reactive with human samples, making it a reliable tool for Western blot applications. By binding to the DIS3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in RNA biology and gene regulation.The DIS3 protein, a conserved exoribonuclease, plays a crucial role in maintaining RNA integrity and controlling gene expression.
Dysregulation of DIS3 activity has been linked to various diseases, including cancer and neurodegenerative disorders. Understanding the function of DIS3 is essential for unraveling its role in these pathological conditions and exploring potential therapeutic strategies. The DIS3 Polyclonal Antibody offers researchers a valuable tool for investigating the mechanisms underlying RNA degradation and gene regulation, contributing to advancements in the field of molecular biology.
Product Name:
DIS3 Rabbit Polyclonal Antibody
SKU:
CAB8027
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DIS3 (NP_055768.3).
Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex).
Purification Method:
Affinity purification
Gene ID:
22894
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DIS3 Rabbit pAb (CAB8027) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
