The DIRAS1 Polyclonal Antibody (PAC019576) is a valuable tool for researchers studying DIRAS1, a protein involved in cell signaling pathways and cellular processes. This antibody, generated in rabbits, exhibits high reactivity with DIRAS1 in human samples and is validated for use in Western blot applications. By binding to the DIRAS1 protein, this antibody allows for precise detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and cancer research.
DIRAS1, also known as Ras-related GTP-binding protein 1, plays a crucial role in regulating cell growth, differentiation, and survival. Its involvement in intracellular signaling cascades makes it a key player in numerous physiological and pathological processes. Research on DIRAS1 is essential for understanding its function in diseases such as cancer and neurological disorders, offering insights that could guide the development of targeted therapies in the future.
Antibody Name:
DIRAS1 Antibody (PACO19576)
Antibody SKU:
PACO19576
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human DIRAS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19576(DIRAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19576(DIRAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
DIRAS1 (DIRAS family, GTP-binding Ras-like 1), also known as distinct subgroup of the Ras family member 1, RIG (Ras-related inhibitor of cell growth), small GTP-binding tumor suppressor 1 or GBTS1, is a 198 amino acid, cell membrane protein expressed at high levels in brain and heart. DIRAS1 displays low GTPase activity and is encoded by a gene that maps to human chromosome 19p13.3.
Synonyms:
DIRAS family, GTP-binding RAS-like 1
UniProt Protein Function:
DIRAS1: Displays low GTPase activity and exist predominantly in the GTP-bound form. Belongs to the small GTPase superfamily. Di-Ras family.Protein type: G protein, monomeric, di-Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: GTP binding; GTPase activity; mitogen-activated protein kinase bindingBiological Process: positive regulation of MAP kinase activity
UniProt Protein Details:
NCBI Summary:
DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
