The DIRAS1 Polyclonal Antibody (PAC019575) is a valuable tool for researchers studying DIRAS1, a protein involved in intracellular signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the DIRAS1 protein, this antibody enables detection and analysis in various cell types, making it ideal for studies in oncology, cell biology, and signal transduction research.DIRAS1, a member of the Ras superfamily of GTPases, plays a key role in regulating cell growth, proliferation, and differentiation.
Dysregulation of DIRAS1 has been implicated in various cancers, making it an attractive target for drug development and therapeutic interventions. By investigating the function and expression of DIRAS1, researchers can gain valuable insights into the molecular mechanisms underlying cancer progression and potentially identify novel targets for treatment strategies.
Antibody Name:
DIRAS1 Antibody (PACO19575)
Antibody SKU:
PACO19575
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human DIRAS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19575(DIRAS1 Antibody) at dilution 1/52, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19575(DIRAS1 Antibody) at dilution 1/52, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
DIRAS1 (DIRAS family, GTP-binding Ras-like 1), also known as distinct subgroup of the Ras family member 1, RIG (Ras-related inhibitor of cell growth), small GTP-binding tumor suppressor 1 or GBTS1, is a 198 amino acid, cell membrane protein expressed at high levels in brain and heart. DIRAS1 displays low GTPase activity and is encoded by a gene that maps to human chromosome 19p13.3.
Synonyms:
DIRAS family, GTP-binding RAS-like 1
UniProt Protein Function:
DIRAS1: Displays low GTPase activity and exist predominantly in the GTP-bound form. Belongs to the small GTPase superfamily. Di-Ras family.Protein type: G protein, monomeric, di-Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: GTP binding; GTPase activity; mitogen-activated protein kinase bindingBiological Process: positive regulation of MAP kinase activity
UniProt Protein Details:
NCBI Summary:
DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
