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Dio3 Antibody (PACO34546)

SKU:
PACO34546
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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Dio3 Antibody (PACO34546)

The DIO3 Polyclonal Antibody (PACO34546) is a valuable tool for researchers studying DIO3, a crucial enzyme involved in thyroid hormone metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards DIO3 in human samples, making it ideal for use in Western blot applications. By targeting the DIO3 protein, researchers can accurately detect and analyze its expression in various biological samples, facilitating research in endocrinology and metabolic disorders.DIO3, also known as type 3 iodothyronine deiodinase, plays a pivotal role in the regulation of thyroid hormone activity by converting the active thyroid hormone T3 into its inactive form, rT3.

Dysregulation of DIO3 has been linked to thyroid dysfunction, metabolic disorders, and cardiovascular diseases, highlighting its clinical relevance. Investigating the function and expression of DIO3 using this antibody can provide insights into thyroid hormone metabolism and potential therapeutic strategies for related conditions.In summary, the DIO3 Polyclonal Antibody (PACO34546) offers researchers a reliable tool for studying DIO3 in various biological contexts, contributing to advancements in the understanding and treatment of thyroid-related disorders.

Antibody Name:Dio3 Antibody (PACO34546)
Antibody SKU:PACO34546
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Synonyms:Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase), Dio3, Itdi3 Txdi3
UniProt Protein Function:DIO3: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Belongs to the iodothyronine deiodinase family.
UniProt Protein Details:

Protein type:EC 1.97.1.11; Oxidoreductase; Membrane protein, integral

Cellular Component: endosome membrane; integral to membrane; plasma membrane

Molecular Function:thyroxine 5'-deiodinase activity; thyroxine 5-deiodinase activity

Biological Process: hormone biosynthetic process; positive regulation of multicellular organism growth; response to hypoxia; thyroid hormone catabolic process; thyroid hormone metabolic process

NCBI Summary:The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. It contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
UniProt Code:P49897
NCBI GenInfo Identifier:255982585
NCBI Gene ID:29475
NCBI Accession:NP_058906.3
UniProt Related Accession:P49897
Molecular Weight:29.5 kDa
NCBI Full Name:thyroxine 5-deiodinase
NCBI Synonym Full Names:deiodinase, iodothyronine, type III
NCBI Official Symbol:Dio3  
NCBI Official Synonym Symbols:5DIII; DIOIII  
NCBI Protein Information:thyroxine 5-deiodinase
UniProt Protein Name:Thyroxine 5-deiodinase
UniProt Synonym Protein Names:5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase
Protein Family:Thyroxine 5-deiodinase
UniProt Gene Name:Dio3  
UniProt Entry Name:IOD3_RAT

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