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DIO1 Antibody (PACO34530)

SKU:
PACO34530
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
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Description

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DIO1 Antibody (PACO34530)

The DIO1 Polyclonal Antibody (PACO34530) is a valuable tool for researchers studying the DIO1 gene, which encodes for the enzyme responsible for converting the prohormone thyroxine (T4) into the active thyroid hormone triiodothyronine (T3). This antibody, produced in rabbits, is highly specific for human DIO1 and has been validated for use in various applications, including Western blot and immunohistochemistry.DIO1 plays a crucial role in thyroid hormone metabolism, impacting various physiological processes such as metabolism, growth, and development. Dysregulation of DIO1 activity has been associated with thyroid disorders, metabolic dysfunction, and other health conditions.

By targeting the DIO1 protein, researchers can investigate its role in these processes and explore potential therapeutic interventions.This antibody is an essential tool for scientists studying thyroid function, metabolism, and related disorders. Its high specificity and sensitivity make it ideal for detecting and analyzing DIO1 expression in tissue samples, cell lines, and other experimental models. By using the DIO1 Polyclonal Antibody, researchers can advance our understanding of thyroid hormone regulation and its implications for human health.

Antibody Name:DIO1 Antibody (PACO34530)
Antibody SKU:PACO34530
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Type I iodothyronine deiodinase protein (34-249AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Synonyms:Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase), DIO1, ITDI1 TXDI1
UniProt Protein Function:DIO1: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. Belongs to the iodothyronine deiodinase family. 9 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 1.97.1.10; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: plasma membrane

Molecular Function:selenium binding; thyroxine 5'-deiodinase activity

Biological Process: thyroid hormone generation

NCBI Summary:The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
UniProt Code:P49895
NCBI GenInfo Identifier:182702125
NCBI Gene ID:1733
NCBI Accession:P49895.3
UniProt Secondary Accession:P49895,Q1RN02, Q3KNP8, Q6Q4C1, Q6Q4C2, Q6Q4C3, Q6Q4C4 Q6Q4C5, Q6Q4C6, Q6Q4C7, Q6Q4C9, Q8WWC6,
UniProt Related Accession:P49895
Molecular Weight:9,774 Da
NCBI Full Name:Type I iodothyronine deiodinase
NCBI Synonym Full Names:deiodinase, iodothyronine type I
NCBI Official Symbol:DIO1  
NCBI Official Synonym Symbols:5DI; TXDI1  
NCBI Protein Information:type I iodothyronine deiodinase
UniProt Protein Name:Type I iodothyronine deiodinase
UniProt Synonym Protein Names:5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase
Protein Family:Type I iodothyronine deiodinase
UniProt Gene Name:DIO1  
UniProt Entry Name:IOD1_HUMAN

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