MonoMethyl-UHRF1-K385 Rabbit Polyclonal Antibody (CAB16008)
- SKU:
- CAB16008
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | MonoMethyl-UHRF1-K385 Rabbit Polyclonal Antibody |
SKU: | CAB16008 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1). |
Sequence: | KAKM A |
Tested Applications: | WB ELISA DB |
Recommended Dilution: | DB,1:500 - 1:2000 WB,1:500 - 1:2000 |
Synonyms: | Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95; MonoMethyl-UHRF1-K385 |
Positive Sample: | C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 90kDa |
Observed MW: | 91kDa |
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Purification Method: | Affinity purification |
Gene ID: | 29128 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |