The Dimethyl-DNMT3A (K44) Polyclonal Antibody (CAB16012) is a powerful tool for researchers studying epigenetics and DNA methylation. This antibody, raised in rabbits, specifically targets the Dimethyl-DNMT3A (K44) protein, allowing for accurate detection and analysis in a variety of cell types. It is highly reactive with human samples and has been validated for use in Western blot applications.DNMT3A is a key enzyme involved in the establishment and maintenance of DNA methylation patterns, playing a crucial role in gene regulation and cellular differentiation. The Dimethyl-DNMT3A (K44) antibody enables researchers to investigate the function and regulation of this important protein, making it an invaluable tool for epigenetics and cancer research.
Understanding the role of DNMT3A and its methylation activity is essential for unraveling the complexities of gene expression and epigenetic changes associated with various diseases, including cancer. By utilizing the Dimethyl-DNMT3A (K44) antibody, researchers can gain deeper insights into the mechanisms underlying disease development and potentially identify new therapeutic targets for precision medicine approaches.
Product Name:
DiMethyl-DNMT3A-K44 Rabbit Polyclonal Antibody
SKU:
CAB16012
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic dimethylated peptide around K44 of mouse DNMT3A (NP_031898.1).
Sequence:
ARKV G
Tested Applications:
IF/ICCELISA
Recommended Dilution:
IF/ICC,1:50 - 1:200
Synonyms:
MmuIIIA; DiMethyl-DNMT3A-K44
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
102kDa
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
13435
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using DiMethyl-DNMT3A-K44 antibody (CAB16012) at dilution of 1:100. Blue: DAPI for nuclear staining.
