The Dihydropyrimidinase Polyclonal Antibody (CAB6368) is a valuable tool for researchers studying dihydropyrimidinase, an enzyme involved in the catabolism of pyrimidines. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the dihydropyrimidinase protein, this antibody allows for the detection and analysis of dihydropyrimidinase levels in various cell types, making it ideal for studies in biochemistry and molecular biology.Dihydropyrimidinase plays a crucial role in the breakdown of pyrimidine nucleotides, which are essential for DNA and RNA synthesis.
Dysregulation of dihydropyrimidinase activity has been linked to various diseases, including pyrimidine metabolism disorders and certain types of cancer. Understanding the function and regulation of dihydropyrimidinase is critical for advancing research in these areas and developing targeted therapies. This polyclonal antibody provides a reliable tool for investigating the role of dihydropyrimidinase in health and disease.
Product Name:
DPYS Rabbit Polyclonal Antibody
SKU:
CAB6368
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1).
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Purification Method:
Affinity purification
Gene ID:
1807
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DPYS antibody (CAB6368) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
