The Dicer1 Polyclonal Antibody (CAB15799) is a valuable tool for researchers studying Dicer1, a key enzyme involved in RNA interference and microRNA processing. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Dicer1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and gene regulation.Dicer1 plays a central role in the RNA interference pathway, functioning to cleave double-stranded RNA into small interfering RNA molecules that regulate gene expression.
Dysregulation of Dicer1 has been linked to various diseases, including cancer, neurodegenerative disorders, and viral infections. By understanding the function and expression of Dicer1, researchers can unravel the mechanisms underlying these diseases and potentially identify novel therapeutic targets.Overall, the Dicer1 Polyclonal Antibody (CAB15799) is a reliable and versatile tool for investigating the intricate role of Dicer1 in gene silencing and RNA processing pathways, offering valuable insights into the molecular mechanisms driving disease progression and potential therapeutic interventions.
Product Name:
DICER1 Rabbit Polyclonal Antibody
SKU:
CAB15799
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human DICER1 (NP_001258211.1).
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23405
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of 293F, using DICER1 antibody (CAB15799) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
