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Di-Methyl-Histone H3 (Lys27) Antibody (PACO03202)

SKU:
PACO03202
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Di-Methyl-Histone H3 (Lys27) Antibody (PACO03202)

The Di-Methyl Histone H3 Lys27 Antibody (PACO03202) is a powerful tool for researchers studying epigenetics and gene regulation. This antibody, raised in rabbits, specifically targets the di-methylation of histone H3 at lysine 27, a crucial modification involved in transcriptional repression. Validated for use in Western blot and immunohistochemistry applications, this antibody allows for accurate detection and analysis of histone H3 lysine 27 di-methylation in various cell types and tissues. Its high reactivity with human samples ensures reliable and consistent results in research studies.Histone modifications, such as di-methylation of histone H3 at lysine 27, play a key role in regulating gene expression and chromatin structure.

Dysregulation of these modifications has been linked to various diseases, including cancer and developmental disorders. By targeting histone modifications with specific antibodies like PACO03202, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets. In conclusion, the Di-Methyl Histone H3 Lys27 Antibody (PACO03202) is a valuable tool for studying epigenetic regulation and chromatin dynamics, with applications in cancer research, developmental biology, and epigenetics.

Antibody Name:Di-Methyl-Histone H3 (Lys27) Antibody
Antibody SKU:PACO03202
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/
UniProt Protein Function:H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: extracellular region; membrane; nuclear chromosome; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleus; protein complex

Molecular Function:cadherin binding; histone binding; protein binding

Biological Process: blood coagulation; cellular protein metabolic process; chromatin silencing at rDNA; DNA replication-dependent nucleosome assembly; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; nucleosome assembly; positive regulation of gene expression, epigenetic; protein heterotetramerization; RNA-mediated gene silencing; telomere organization and biogenesis

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Code:P68431
NCBI GenInfo Identifier:55977055
NCBI Gene ID:8357
NCBI Accession:P68431.2
UniProt Secondary Accession:P68431,P02295, P02296, P16106, Q6ISV8, Q6NWP8, Q6NWP9 Q6NXU4, Q71DJ3, Q93081, A0PJT7, A5PLR1,
UniProt Related Accession:P68431
Molecular Weight:15kDa
NCBI Full Name:Histone H3.1
NCBI Synonym Full Names:histone cluster 1 H3 family member h
NCBI Official Symbol:HIST1H3H  
NCBI Official Synonym Symbols:H3/k; H3FK; H3F1K  
NCBI Protein Information:histone H3.1
UniProt Protein Name:Histone H3.1
UniProt Synonym Protein Names:Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
UniProt Gene Name:HIST1H3A  

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