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Anti-Di-methyl-Histone H3(K79) Antibody (MACO0086)

SKU:
MACO0086
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Mouse
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Monoclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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Anti-Di-methyl-Histone H3(K79) Antibody (MACO0086)

The Di-Methyl Histone H3 K79 Monoclonal Antibody (MACO0086) is a crucial tool for researchers studying epigenetics and chromatin regulation. This monoclonal antibody, produced using advanced technology, specifically targets the di-methylated form of histone H3 at lysine 79, a key histone modification associated with gene regulation and cell signaling.Histone modifications, such as di-methylation of histone H3 at K79, play a critical role in regulating gene expression and chromatin structure. The MACO0086 antibody allows for precise detection and analysis of this specific histone modification, providing important insights into cell function, differentiation, and disease progression.

This antibody is highly sensitive and specific for detecting di-methyl histone H3 K79 in a variety of sample types, making it an invaluable tool for studies in cancer research, developmental biology, and epigenetics. Its reliable performance in techniques such as Western blotting and immunohistochemistry make it a versatile choice for researchers seeking to understand the complex mechanisms governing gene expression and cellular identity.

Product Name:Anti-Di-methyl-Histone H3(K79) Antibody
Product Sku:MACO0086
Size:50ug
Host Species:Mouse
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:5000
Species Reactivity:Human,Mouse,Rat
Immunogen:Synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clonality:Monoclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:
Synonyms:HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/
Product ImageWestern blot analysis of 1) Hela, 2) Raw264.7, 3) Rat Brain Tissue, diluted at 1:2000.
UniProt Protein Function:H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: extracellular region; membrane; nuclear chromosome; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleus; protein complex

Molecular Function:cadherin binding; histone binding; protein binding

Biological Process: blood coagulation; cellular protein metabolic process; chromatin silencing at rDNA; DNA replication-dependent nucleosome assembly; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; nucleosome assembly; positive regulation of gene expression, epigenetic; protein heterotetramerization; RNA-mediated gene silencing; telomere organization and biogenesis

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Code:P68431
NCBI GenInfo Identifier:55977055
NCBI Gene ID:8357
NCBI Accession:P68431.2
UniProt Secondary Accession:P68431,P02295, P02296, P16106, Q6ISV8, Q6NWP8, Q6NWP9 Q6NXU4, Q71DJ3, Q93081, A0PJT7, A5PLR1,
UniProt Related Accession:P68431
Molecular Weight:15kDa
NCBI Full Name:Histone H3.1
NCBI Synonym Full Names:histone cluster 1 H3 family member h
NCBI Official Symbol:HIST1H3H  
NCBI Official Synonym Symbols:H3/k; H3FK; H3F1K  
NCBI Protein Information:histone H3.1
UniProt Protein Name:Histone H3.1
UniProt Synonym Protein Names:Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
UniProt Gene Name:HIST1H3A  

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