The Di-Methyl Histone H1 Lys25 Polyclonal Antibody (PACO00145) is a valuable tool for researchers studying histone modifications and chromatin structure. This antibody, produced in rabbits, specifically binds to the di-methylated form of histone H1 at lysine 25, allowing for the detection and analysis of this histone modification in various biological samples.Histone modifications play a crucial role in the regulation of gene expression and chromatin remodeling, and understanding the function of specific histone modifications like di-methylation at lysine 25 of histone H1 is essential for unraveling the complexities of epigenetic regulation.
The Di-Methyl Histone H1 Lys25 Antibody is validated for use in applications such as Western blotting, immunoprecipitation, and immunofluorescence, making it a versatile tool for researchers in the fields of epigenetics, chromatin biology, and cancer research.By using the Di-Methyl Histone H1 Lys25 Antibody, researchers can further explore the role of histone modifications in gene regulation, cell differentiation, and disease development, paving the way for new insights and potential therapeutic strategies in various biological processes.
Antibody Name:
Di-Methyl-Histone H1 (Lys25) Antibody
Antibody SKU:
PACO00145
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
