UniProt Protein Function: | DDX16: a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. Probable ATP-binding RNA helicase involved in pre-mRNA splicing. Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA-binding; SpliceosomeChromosomal Location of Human Ortholog: 6p21.33Cellular Component: cytoplasm; nucleoplasm; nucleus; spliceosomal complexMolecular Function: ATP binding; ATP-dependent RNA helicase activity; ATPase activity; protein binding; RNA binding; RNA helicase activityBiological Process: mRNA splicing, via spliceosome; RNA splicing |
UniProt Protein Details: | |
NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] |
UniProt Code: | O60231 |
NCBI GenInfo Identifier: | 256000749 |
NCBI Gene ID: | 8449 |
NCBI Accession: | NP_001157711.1 |
UniProt Secondary Accession: | O60231,O60322, Q5JP45, Q969X7, Q96QC1 |
UniProt Related Accession: | O60231 |
Molecular Weight: | 119,264 Da |
NCBI Full Name: | putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2 |
NCBI Synonym Full Names: | DEAH-box helicase 16 |
NCBI Official Symbol: | DHX16Â Â |
NCBI Official Synonym Symbols: | DBP2; PRP8; Prp2; DDX16; PRPF2; PRO2014Â Â |
NCBI Protein Information: | putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
UniProt Protein Name: | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
UniProt Synonym Protein Names: | ATP-dependent RNA helicase #3; DEAH-box protein 16 |
Protein Family: | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase |
UniProt Gene Name: | DHX16Â Â |
UniProt Entry Name: | |