The DHRS4 Polyclonal Antibody (CAB10285) is a valuable tool for researchers studying DHRS4, a key enzyme involved in the metabolism of retinoids and steroids. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the DHRS4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component in studies related to metabolism, pharmacology, and endocrinology.DHRS4, also known as dehydrogenase/reductase SDR family member 4, plays a crucial role in the biosynthesis and degradation of retinoids and steroids, which are essential for various physiological functions including vision, reproduction, and immune response.
Dysregulation of DHRS4 has been implicated in diseases such as cancer, metabolic disorders, and neurodegenerative conditions, highlighting the importance of studying this enzyme for potential therapeutic interventions.Overall, the DHRS4 Polyclonal Antibody is an indispensable tool for researchers aiming to deepen their understanding of DHRS4 function and its implications in health and disease. Its high specificity and sensitivity make it a reliable choice for experiments ranging from basic research to drug development efforts targeting retinoid and steroid metabolism pathways.
Product Name:
DHRS4 Rabbit Polyclonal Antibody
SKU:
CAB10285
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2).
HeLa,LO2,A-549,MCF7,SW620,Mouse liver,Mouse lung,Mouse small intestine,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, Peroxisome.
Calculated MW:
30kDa
Observed MW:
30kDa
Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane.
Purification Method:
Affinity purification
Gene ID:
10901
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DHRS4 antibody (CAB10285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
