The DHPS Polyclonal Antibody (CAB6367) is a high-quality antibody designed for research involving DHPS, a key enzyme in the folate biosynthesis pathway. This antibody, raised in rabbits, is highly specific and reactive with human samples, validated for use in various applications such as Western blot and immunohistochemistry.DHPS, also known as dihydropteroate synthase, is essential for the synthesis of folate, a crucial coenzyme involved in nucleotide biosynthesis and amino acid metabolism. Inhibition of DHPS has been a target for antimicrobial drugs, particularly in the treatment of bacterial infections such as those caused by Pneumocystis jirovecii and Plasmodium species.
Research into DHPS and its role in folate metabolism is important for understanding drug resistance mechanisms, developing new therapeutic interventions, and exploring potential drug targets for infectious diseases. The DHPS Polyclonal Antibody provides a powerful tool for studying DHPS expression and function in various biological contexts, making it an essential reagent for researchers in the fields of microbiology, infectious diseases, and drug development.
Product Name:
DHPS Rabbit Polyclonal Antibody
SKU:
CAB6367
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human DHPS (NP_001921.1).
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
1725
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using DHPS antibody (CAB6367) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
