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DHFR Monoclonal Antibody [PAT5B2AT] (CPAB0210)

SKU:
CPAB0210
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT5B2AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

DHFR Monoclonal Antibody [PAT5B2AT] (CPAB0210)

The DHFR Polyclonal Antibody (CPAB0210) is a valuable tool for researchers studying dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism and essential for cell growth and division. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blotting applications.DHFR is a key target in cancer therapy, as it plays a crucial role in DNA synthesis and repair. Overexpression of DHFR has been linked to resistance to certain chemotherapeutic agents, making it a promising target for drug development.

By using the DHFR Polyclonal Antibody, researchers can detect and analyze DHFR expression in various cell types, aiding in the understanding of its role in cancer and potentially identifying new therapeutic interventions.Overall, the DHFR Polyclonal Antibody is a reliable tool for studies in cancer biology, pharmacology, and drug development, providing valuable insights into the function and regulation of DHFR in health and disease.

Product Name:DHFR Antibody
Product Sku:CPAB0210
Size:5μg
Host Species:Mouse
Immunogen:Anti-human DHFR mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human DHFR amino acids 1-187 purified from Ecoli.
Clone:PAT5B2AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:DHFR antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Dihydrofolate reductase (DHFR) is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, with NADPH as electron donor that can be converted to the kinds of tetrahydrofolate cofactors applied in 1-carbon transfer chemistry. DHFR converts dihydrofolate into tetrahydrofolate, which is a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and specific amino acids. Even though the functional DHFR gene is mapped to chromosome 5, numerous intronless processed pseudogenes or dihydrofolate reductase-like genes are identified on separate chromosomes. DHFR deficiency is associated with megaloblastic anemia.DHFR knockdown plays a role in the anticancer activity of 2-hydroxyoleic acid. DHFR gene insertion/deletion polymorphism is linked to variation in serum and red blood cell folate concentrations in women.
Synonyms:Dihydrofolate reductase, DHFR, DHFRP1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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