The DHDDS Polyclonal Antibody (CAB7835) is a valuable tool for researchers studying the DHDDS protein, which is involved in the mevalonate pathway and plays a crucial role in the biosynthesis of isoprenoids. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal choice for Western blot applications.DHDDS is essential for the production of isoprenoid compounds that are involved in various cellular functions, including protein prenylation and cholesterol biosynthesis.
Dysregulation of the mevalonate pathway, including DHDDS, has been implicated in diseases such as cancer, Alzheimer's, and cardiovascular disorders. By using the DHDDS Polyclonal Antibody, researchers can study the expression and function of DHDDS in different cell types and tissues, advancing our understanding of its role in health and disease.
Product Name:
DHDDS Rabbit Polyclonal Antibody
SKU:
CAB7835
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human DHDDS (NP_995583.1).
The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
79947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DHDDS antibody (CAB7835) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
