DHCR24 Rabbit Polyclonal Antibody (CAB5402)
- SKU:
- CAB5402
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | DHCR24 Rabbit Polyclonal Antibody |
SKU: | CAB5402 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1). |
Sequence: | AEIR IIPA KKYV KLRF EPVR GLEA ICAK FTHE SQRQ ENHF VEGL LYSL DEAV IMTG VMTD EAEP SKLN SIGN YYKP WFFK HVEN YLKT NREG LEYI PLRH YYHR HTRS IFWE LQDI IPFG NNPI FRYL FGWM VPPK ISLL KLTQ GETL RKLY EQHH VVQD MLVP MKCL QQAL HTFQ NDIH VYPI WLCP FILP SQPG LVHP KGNE AELY IDIG AYGE PRVK HFEA RSCM RQLE KFVR SVHG FQML YADC YMNR EEFW EMFD GSLY HKLR EKLG CQDA FPEV YDKI CKAA RH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DCE; SELADIN1; Nbla03646; seladin-1; DHCR24 |
Positive Sample: | U-87MG,HT-29,PC-12,NCI-H460 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass membrane protein. |
Calculated MW: | 60kDa |
Observed MW: | 55kDa |
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Purification Method: | Affinity purification |
Gene ID: | 1718 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |