The DGUOK Polyclonal Antibody (CAB6898) is a valuable tool for research involving DGUOK, a key enzyme involved in mitochondrial DNA replication. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it ideal for use in Western blot applications. By binding to the DGUOK protein, this antibody allows for the precise detection and analysis of DGUOK in a variety of cell types.DGUOK is essential for maintaining mitochondrial DNA integrity and mutations in the DGUOK gene have been linked to mitochondrial DNA depletion syndromes.
Research on DGUOK is crucial for understanding the molecular mechanisms underlying these disorders and developing potential therapeutic interventions.The DGUOK Polyclonal Antibody is a reliable tool for studying the function of DGUOK in normal and diseased states, making it a valuable resource for researchers in the fields of genetics, molecular biology, and mitochondrial biology.
Product Name:
DGUOK Rabbit Polyclonal Antibody
SKU:
CAB6898
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-277 of human DGUOK (NP_550438.1).
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1716
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DGUOK antibody (CAB6898) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
