The DGCR8 Rabbit Monoclonal Antibody (CAB3977) is a valuable tool for researchers studying RNA processing and microRNA biogenesis. This antibody is raised in rabbits and is highly specific to DGCR8, a key protein involved in microRNA maturation. DGCR8 plays a crucial role in the microRNA processing pathway, where it helps in the cleavage of precursor miRNA into mature miRNA. Dysregulation of DGCR8 has been linked to various diseases, including cancer and neurodevelopmental disorders.
This antibody is validated for use in Western blot applications and allows for the detection and analysis of DGCR8 in various cell types. With its high specificity and sensitivity, the DGCR8 Rabbit Monoclonal Antibody is an essential tool for researchers in the fields of molecular biology, genetics, and cancer research. Unlock the potential of microRNA biogenesis with this powerful research tool.
Product Name:
DGCR8 Rabbit Monoclonal Antibody
SKU:
CAB3977
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 436-764 of human DGCR8 (Q8WYQ5).
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
54487
Clone Number:
ARC0289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DGCR8 Rabbit mAb (CAB3977) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
