DFFB Rabbit Polyclonal Antibody (CAB10110)
- SKU:
- CAB10110
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | DFFB Rabbit Polyclonal Antibody |
SKU: | CAB10110 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 109-338 of human DFFB (NP_004393.1). |
Sequence: | DEQA PQRQ RLLA DLLH NVSQ NIAA ETRA EDPP WFEG LESR FQSK SGYL RYSC ESRI RSYL REVS SYPS TVGA EAQE EFLR VLGS MCQR LRSM QYNG SYFD RGAK GGSR LCTP EGWF SCQG PFDM DSCL SRHS INPY SNRE SRIL FSTW NLDH IIEK KRTI IPTL VEAI KEQD GREV DWEY FYGL LFTS ENLK LVHI VCHK KTTH KLNC DPSR IYKP QTRL KRKQ PVRK RQ |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | CAD; CPAN; DFF2; DFF40; DFF-40; DFFB |
Positive Sample: | A-549,K-562,SW620,Mouse spleen,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 39kDa |
Observed MW: | 39kDa |
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 1677 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |