The Desmoplakin Polyclonal Antibody (CAB7635) is a valuable tool for researchers studying desmoplakin, a protein essential for cell-cell adhesion in tissues like skin and heart muscle. This antibody, raised in rabbits, is specifically reactive with desmoplakin in human samples and is validated for use in various applications, including Western blotting.Desmoplakin plays a crucial role in maintaining the structural integrity of tissues by anchoring intermediate filaments to desmosomes, structures that provide strength and flexibility to cells. Dysregulation of desmoplakin function has been implicated in diseases like cardiomyopathies and skin disorders, highlighting the importance of understanding its role in tissue integrity.
By using the Desmoplakin Polyclonal Antibody, researchers can easily detect and analyze desmoplakin expression in different cell types and tissues, providing insights into its function and potential implications for various pathologies. This antibody is a valuable tool for studies in cell biology, tissue engineering, and disease research related to desmosome function.
Product Name:
Desmoplakin Rabbit Polyclonal Antibody
SKU:
CAB7635
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Desmoplakin (NP_004406.2).
This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1832
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Desmoplakin Rabbit pAb (CAB7635) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
