The Desmoglein 3 Rabbit Monoclonal Antibody (CAB5227) is essential for research involving Desmoglein 3, a key protein involved in cell-cell adhesion in epithelial tissues. This highly reactive antibody, generated in rabbits, is validated for use in various applications such as immunohistochemistry and Western blotting. It specifically binds to the Desmoglein 3 protein, allowing for accurate detection and analysis in different cell types.Desmoglein 3 is a critical component of desmosomes, which play a crucial role in maintaining tissue integrity and barrier function in the skin and mucous membranes. Dysregulation of Desmoglein 3 has been implicated in various skin diseases, including pemphigus vulgaris, a potentially life-threatening autoimmune disorder.
Research using this antibody can provide valuable insights into the role of Desmoglein 3 in these conditions, paving the way for the development of targeted therapies. Overall, the Desmoglein 3 Rabbit Monoclonal Antibody (CAB5227) is a valuable tool for scientists studying cell adhesion, epithelial biology, and dermatological disorders. Its high specificity and sensitivity make it an indispensable resource for advancing research in these areas.
Product Name:
Desmoglein 3 Rabbit Monoclonal Antibody
SKU:
CAB5227
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900-999 of human Desmoglein 3 (P32926).
Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Calculated MW:
108kDa
Observed MW:
145kDa
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
Purification Method:
Affinity purification
Gene ID:
1830
Clone Number:
ARC1190
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Desmoglein 3 Rabbit mAb (CAB5227) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
