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DSG1 Rabbit Polyclonal Antibody (CAB9812)

SKU:
CAB9812
Product Type:
Antibody
Applications:
WB
IHC
IF
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 12 Anti-Desmoglein-1 Antibody CAB9812
  • Cell Biology Antibodies 12 Anti-Desmoglein-1 Antibody CAB9812
  • Cell Biology Antibodies 12 Anti-Desmoglein-1 Antibody CAB9812
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:DSG1 Rabbit Polyclonal Antibody
SKU:CAB9812
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-1049 of human DSG1 (NP_001933.2).
Sequence:SPHF GTTT VISE STYP SGPG VLHP KPIL DPLG YGNV TVTE SYTT SDTL KPSV HVHD NRPA SNVV VTER VVGP ISGA DLHG MLEM PDLR DGSN VIVT ERVI APSS SLPT SLTI HHPR ESSN VVVT ERVI QPTS GMIG SLSM HPEL ANAH NVIV TERV VSGA GVTG ISGT TGIS GGIG SSGL VGTS MGAG SGAL SGAG ISGG GIGL SSLG GTAS IGHM RSSS DHHF NQTI GSAS PSTA RSRI TKYS TVQY SK
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100
Synonyms:DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; DSG1
Positive Sample:A-431,HeLa,293T,BT-474
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Calculated MW:114kDa
Observed MW:150kDa

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.

Purification Method:Affinity purification
Gene ID:1828
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using DSG1 antibody (CAB9812) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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