Desmocollin 3 Polyclonal Antibody (CAB22232)
- SKU:
- CAB22232
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Desmocollin 3 Polyclonal Antibody |
SKU: | CAB22232 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 576-690 of human Desmocollin 3 (NP_001932.2). |
Sequence: | EILQ EYVV ICKP KMGY TDIL AVDP DEPV HGAP FYFS LPNT SPEI SRLW SLTK VNDT AARL SYQK NAGF QEYT IPIT VKDR AGQA ATKL LRVN LCEC THPT QCRA TSRS TGVI LGK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; Desmocollin 3 |
Positive Sample: | Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cell junction, cell-cell junction, cytoplasm, desmosome, extracellular region, plasma membrane |
Calculated MW: | 100kDa |
Observed MW: | 102kDa |
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1825 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |