The Desmocollin-1 Polyclonal Antibody (CAB10061) is a valuable tool for researchers studying Desmocollin-1, a cell adhesion molecule essential for maintaining the integrity of epithelial tissues. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Desmocollin-1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and dermatology.Desmocollin-1 is a key component of desmosomes, specialized structures that facilitate cell-cell adhesion and tissue stability.
Dysregulation of Desmocollin-1 has been implicated in skin disorders such as pemphigus vulgaris and various forms of dermatitis. By studying the function and expression of Desmocollin-1, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for treating them.Overall, the Desmocollin-1 Polyclonal Antibody (CAB10061) serves as a valuable tool for investigating the role of Desmocollin-1 in epithelial cell adhesion and tissue homeostasis, offering a potential avenue for advancing our understanding of skin diseases and potentially developing new treatments.
Product Name:
DSC1 Rabbit Polyclonal Antibody
SKU:
CAB10061
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1).
Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Calculated MW:
100kDa
Observed MW:
100kDa
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
Purification Method:
Affinity purification
Gene ID:
1823
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DSC1 antibody (CAB10061) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
