DSC1 Rabbit Polyclonal Antibody (CAB10061)
- SKU:
- CAB10061
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | DSC1 Rabbit Polyclonal Antibody |
SKU: | CAB10061 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1). |
Sequence: | SQDG FPAG QELL GYKA LDPE ISSG EGLR YQKL GDED NWFE INQH TGDL RTLK VLDR ESKF VKNN QYNI SVVA VDAV GRSC TGTL VVHL DDYN DHAP QIDK EVTI CQNN EDFA VLKP VDPD GPEN GPPF QFFL DNSA SKNW NIEE KDGK TAIL RQRQ NLDY NYYS VPIQ IKDR HGLV ATHM LTVR VCDC STPS ECRM KDKS TRDV RPNV ILG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CDHF1; DG2/DG3; DSC1 |
Positive Sample: | A375,RAW264.7,LNCaP,Mouse liver,Rat liver,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome. |
Calculated MW: | 100kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
Purification Method: | Affinity purification |
Gene ID: | 1823 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |