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Desmocollin 1 Monoclonal Antibody

SKU:
CAB23580
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

Desmocollin 1 Monoclonal Antibody (CAB23580)

The Desmocollin-1 Monoclonal Antibody is a valuable tool for researchers studying cell adhesion and signaling pathways. This antibody, produced using monoclonal antibody technology, specifically targets Desmocollin-1, a cell adhesion molecule important for maintaining tissue integrity and function.Desmocollin-1 is a member of the desmocollin family of cadherins, which play a key role in cell-cell adhesion and are essential for the formation of strong intercellular junctions. Dysregulation of Desmocollin-1 expression has been linked to various diseases, including cancer and autoimmune disorders. By targeting Desmocollin-1, researchers can investigate its role in disease progression and potentially identify new therapeutic targets.

This antibody is highly specific to human Desmocollin-1 and has been validated for use in various applications, including immunofluorescence and immunohistochemistry. Its high reactivity and specificity make it a reliable tool for studying Desmocollin-1 expression patterns in different cell types and tissues.Overall, the Desmocollin-1 Monoclonal Antibody is an essential reagent for researchers interested in understanding the role of cell adhesion molecules in health and disease. Its versatility and reliability make it a valuable asset for studies in the fields of cell biology, cancer research, and immunology.

Product Name:Desmocollin 1 Monoclonal Antibody
Product Code:CAB23580
Reactivity:Human, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC3133
Reactivity:Human, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:Rat testis
Cellular Location:Cell junction, Cell membrane, Single-pass type I membrane protein, Desmosome

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.

Immunogen:Recombinant protein of human Desmocollin 1.
Sequence:Email for sequence
Synonyms:CDHF1, DG2/DG3
Calculated MW:100kDa
Observed MW:100kDa

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