The Desmin Polyclonal Antibody (CAB0699) is specifically designed for research involving Desmin, a protein that plays a key role in maintaining the structure and function of muscle cells. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.Desmin is a type III intermediate filament protein that is predominantly found in smooth, cardiac, and skeletal muscle tissues. It serves as a marker for muscle differentiation and is essential for muscle cell integrity.
The Desmin Polyclonal Antibody binds specifically to Desmin protein, allowing for the detection and analysis of Desmin expression in different cell types.Research involving Desmin is crucial for understanding various muscle-related disorders such as myopathies, muscular dystrophies, and cardiomyopathies. The Desmin Polyclonal Antibody provides a valuable tool for investigating the role of Desmin in these conditions and can aid in the development of potential therapeutic strategies targeting muscle diseases.
Product Name:
Desmin Rabbit Polyclonal Antibody
SKU:
CAB0699
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human Desmin (NP_001918.3).
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Purification Method:
Affinity purification
Gene ID:
1674
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from C2C12 cells using Desmin Rabbit pAb(CAB0699) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:1s.
