The DES Polyclonal Antibody (CAB1116) is a valuable tool for researchers studying DES, a protein involved in various cellular processes including cell division and differentiation. This antibody, generated in rabbits, is highly specific to human DES samples and is validated for use in immunohistochemistry and immunofluorescence applications. It binds specifically to the DES protein, allowing for detection and visualization in different cell types, making it an essential tool for studies in cell biology and cancer research.DES, also known as desmin, is a key component of the cytoskeleton in muscle cells and plays a crucial role in maintaining cell structure and function.
Dysregulation of DES expression has been implicated in various diseases, including muscle disorders and certain cancers. By studying DES protein levels and localization, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the DES Polyclonal Antibody is a reliable and effective tool for investigating the function and regulation of DES in normal and diseased cells, paving the way for new discoveries in the fields of cell biology and disease pathology.
Product Name:
Desmin Rabbit Polyclonal Antibody
SKU:
CAB1116
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Desmin (NP_001918.3).
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Purification Method:
Affinity purification
Gene ID:
1674
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of C2C12 cells, using Desmin antibody (CAB1116) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
