The Dermcidin Polyclonal Antibody (CAB7280) is a specialized research tool designed for the study of dermcidin, a protein involved in the antimicrobial defense of the skin. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. By specifically binding to dermcidin, researchers can accurately detect and analyze this important protein in a variety of cell types, making it an invaluable tool for studies in dermatology, microbiology, and infectious disease research.
Dermcidin is a crucial component of the body's natural defense against pathogens, particularly in the skin where it helps to prevent infection and promote healing. By investigating the role of dermcidin in immune responses and microbial defense, researchers can gain insights into skin health, wound healing, and infectious disease mechanisms. The Dermcidin Polyclonal Antibody offers a reliable and sensitive means of studying dermcidin, advancing our understanding of its functions and potential therapeutic applications.
Product Name:
DCD Rabbit Polyclonal Antibody
SKU:
CAB7280
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human DCD (NP_444513.1).
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
117159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of HeLa, using DCD antibody (CAB7280) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
