The Deoxyribonuclease 1 Polyclonal Antibody (CAB2537) is specifically designed for research involving Deoxyribonuclease 1, an important enzyme involved in the breakdown of DNA. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications including Western blotting. By binding to Deoxyribonuclease 1, this antibody enables accurate detection and analysis of the enzyme in different cell types, making it an excellent tool for studies in molecular biology and genetic research.
Deoxyribonuclease 1 plays a crucial role in the degradation of DNA, and its dysregulation has been linked to various diseases such as autoimmune disorders, cancer, and inflammatory conditions. Understanding the function and mechanisms of Deoxyribonuclease 1 is essential for developing targeted therapies and diagnostic tools for these diseases. This antibody provides researchers with a reliable means to study the expression and activity of Deoxyribonuclease 1, contributing to advancements in the field of molecular biology and medicine.
Product Name:
DNASE1 Rabbit Polyclonal Antibody
SKU:
CAB2537
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-282 of human DNASE1 (NP_005214.2).
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Purification Method:
Affinity purification
Gene ID:
1773
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNASE1 Rabbit pAb (CAB2537) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
