The DENND4A Polyclonal Antibody (CAB16095) is specifically designed for research involving DENND4A, a protein implicated in various cellular processes, including membrane trafficking and signaling pathways. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of DENND4A protein expression in a variety of cell types.DENND4A, also known as a guanine nucleotide exchange factor, plays a crucial role in regulating intracellular transport and membrane dynamics, making it a promising target for further research into cellular mechanisms and disease pathways.
Studies have shown that DENND4A is involved in processes such as endosome trafficking and autophagy, suggesting its importance in maintaining proper cellular function.By utilizing the DENND4A Polyclonal Antibody (CAB16095) in your research, you can gain valuable insights into the function and regulation of DENND4A, potentially uncovering new therapeutic targets for diseases related to membrane trafficking defects or signaling dysregulation. This antibody is an essential tool for researchers in the fields of cell biology, molecular biology, and disease pathology, offering a reliable and specific way to study the role of DENND4A in various biological contexts.
Product Name:
DENND4A Rabbit Polyclonal Antibody
SKU:
CAB16095
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1650 of human DENND4A (NP_005839.3).
This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.
Purification Method:
Affinity purification
Gene ID:
10260
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DENND4A Rabbit pAb (CAB16095) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
