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Anti-delta Sarcoglycan Antibody (CAB9175)

SKU:
CAB9175
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

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Anti-delta Sarcoglycan Antibody (CAB9175)

The Delta-Sarcoglycan Rabbit Monoclonal Antibody (CAB9175) is a cutting-edge tool designed for researchers studying delta-sarcoglycan, a key protein involved in muscle function and regulation. This antibody, developed using rabbit monoclonal technology, offers high reactivity with human samples and is validated for use in various applications, including Western blotting.Delta-sarcoglycan is a critical component of the dystrophin-glycoprotein complex, essential for maintaining muscle integrity and function. Dysregulation of delta-sarcoglycan has been linked to muscular dystrophy and other muscle-related disorders, making it a key target for research in the field of muscle biology.

By specifically binding to the delta-sarcoglycan protein, this antibody enables precise detection and analysis in different cell types, providing valuable insights into the role of delta-sarcoglycan in muscle development and disease. Researchers studying muscular dystrophy, muscle degeneration, and muscle regeneration will find this antibody particularly useful in advancing their studies and understanding of these conditions.

Antibody Name:Anti-delta Sarcoglycan Antibody
Antibody SKU:CAB9175
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human delta Sarcoglycan
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, RD, Mouse heart
Immunogen:A synthesized peptide derived from human delta Sarcoglycan
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6444
Uniprot:Q92629
Cellular Location:
Calculated MW:35kDa
Observed MW:36KDa
Synonyms:35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD
Background:The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Dystrophin complex; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33-q34

Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma

Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development

Disease: Muscular Dystrophy, Limb-girdle, Type 2f; Cardiomyopathy, Dilated, 1l

NCBI Summary:The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q92629
NCBI GenInfo Identifier:212276471
NCBI Gene ID:6444
NCBI Accession:Q92629.2
UniProt Secondary Accession:Q92629,Q53XA5, Q99644, A8K9S9,
UniProt Related Accession:Q92629
Molecular Weight:289
NCBI Full Name:Delta-sarcoglycan
NCBI Synonym Full Names:sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
NCBI Official Symbol:SGCD  
NCBI Official Synonym Symbols:SGD; DAGD; 35DAG; CMD1L; SGCDP; SG-delta  
NCBI Protein Information:delta-sarcoglycan; delta-SG; placental delta sarcoglycan; 35 kDa dystrophin-associated glycoprotein; dystrophin associated glycoprotein, delta sarcoglycan
UniProt Protein Name:Delta-sarcoglycan
UniProt Synonym Protein Names:35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family:Delta-sarcoglycan
UniProt Gene Name:SGCD  
UniProt Entry Name:SGCD_HUMAN
Anti-delta Sarcoglycan Antibody (CAB9175)Western blot - delta Sarcoglycan Rabbit mAb (CAB9175)

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