The Delta Sarcoglycan Polyclonal Antibody (CAB6980) is a valuable tool for researchers studying Delta Sarcoglycan, a protein involved in muscle cell biology and muscular dystrophies. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Delta Sarcoglycan in human samples, making it ideal for Western blot applications.Delta Sarcoglycan is a member of the sarcoglycan complex, which plays a crucial role in maintaining the structural integrity of muscle cells. Mutations in Delta Sarcoglycan have been linked to various forms of muscular dystrophy, including limb-girdle muscular dystrophy.
By utilizing the Delta Sarcoglycan Polyclonal Antibody, researchers can investigate the expression levels and localization of Delta Sarcoglycan in different cell types and tissues, shedding light on its function in normal physiology and disease pathology.Furthermore, understanding the role of Delta Sarcoglycan in muscle health and disease could pave the way for the development of targeted therapies for muscular dystrophies and related disorders. The Delta Sarcoglycan Polyclonal Antibody is a valuable tool for advancing research in this field and unraveling the complexities of muscle biology.
Recombinant fusion protein containing a sequence corresponding to amino acids 61-290 of human Delta-sarcoglycan (Delta-sarcoglycan (SGCD)) (NP_000328.2).
Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytoskeleton, sarcolemma.
Calculated MW:
32kDa
Observed MW:
37kDa
The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
6444
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Delta-sarcoglycan (SGCD) Rabbit pAb (CAB6980) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
