The DEG15 Polyclonal Antibody (PAC0267) is a valuable tool for researchers studying DEG15, a protein involved in cellular processes related to DNA repair and genomic stability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the DEG15 protein, researchers can easily detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and cancer research.
DEG15, also known as DNA endonuclease G15, plays a crucial role in maintaining the integrity of the genome by participating in DNA damage response pathways. Its involvement in DNA repair mechanisms underscores its importance in understanding the cellular response to genotoxic stress and its implications in cancer development. Research on DEG15 can provide valuable insights into potential therapeutic strategies targeting DNA repair pathways in cancer treatment and personalized medicine approaches.
Antibody Name:
DEG15 Antibody (PACO62067)
Antibody SKU:
PACO62067
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana Glyoxysomal processing protease, glyoxysomal protein (572-709AA)
Western Blot. Positive WB detected in: Spinacia oleracea leaf tissue. All lanes: DEG15 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 77 kDa. Observed band size: 77 kDa.
Background:
Trypsin-like serine endopeptidase involved in the processing of glyoxysomal higher molecular weight precursor. The dimeric form carries out the specific cleavages needed to remove PTS2-containing presequences, whereas the monomeric form degrades the removed presequences and misfolded proteins (Probable). Not required for degradation of glyoxylate cycle enzymes during seedling development.
Trypsin-like serine endopeptidase involved in the processing of glyoxysomal higher molecular weight precursor. The dimeric form carries out the specific cleavages needed to remove PTS2-containing presequences, whereas the monomeric form degrades the removed presequences and misfolded proteins (Probable). Not required for degradation of glyoxylate cycle enzymes during seedling development.
UniProt Protein Details:
NCBI Summary:
Mutants in this gene are defective in the processing of pre-glyoxysomal malate dehydrogenase (pre-gMDH) to gMDH.
