The DEFB104A Antibody (PAC038846) is a polyclonal antibody specifically designed for research involving DEFB104A, a gene that encodes for a protein involved in the innate immune response. This antibody, generated in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.DEFB104A, also known as defensin beta 104A, is a member of the defensin family of antimicrobial peptides that play a crucial role in host defense against pathogens. DEFB104A is expressed in various tissues, including the skin, gastrointestinal tract, and respiratory tract, where it helps protect against bacterial, viral, and fungal infections.
Research on DEFB104A is important for understanding its role in antimicrobial defense and how its dysregulation may contribute to diseases such as inflammatory disorders, infectious diseases, and cancer. By studying the expression and function of DEFB104A, researchers can gain insights into novel therapeutic targets for combating various diseases and enhancing the body's immune response. The DEFB104A Antibody is a valuable tool for investigating the functions and mechanisms of DEFB104A in different biological contexts.
Antibody Name:
DEFB104A Antibody (PACO38846)
Antibody SKU:
PACO38846
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Beta-defensin 104 protein (23-72AA)
defensin, beta 4: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Belongs to the beta-defensin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cell surface; extracellular regionBiological Process: defense response to bacterium; innate immune response
UniProt Protein Details:
NCBI Summary:
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
