The DEFA6 Antibody (PAC015816) is a highly specific and sensitive tool for researchers studying the DEFA6 protein, which is involved in the immune response and inflammation processes. This polyclonal antibody was raised in rabbits and is proven to be reactive with human samples, making it an excellent choice for studies in immunology and related fields.DEFA6, also known as defensin alpha 6, is a member of the defensin protein family that plays a key role in the innate immune response by targeting and eliminating pathogens. Its expression is upregulated in response to infection or inflammation, highlighting its importance in host defense mechanisms.
The DEFA6 Antibody enables researchers to detect and analyze DEFA6 protein levels in various cell types, providing valuable insights into how it functions in health and disease.Researchers studying infectious diseases, inflammatory conditions, or immune pathways will benefit from using the DEFA6 Antibody in techniques such as Western blotting. By understanding the role of DEFA6 in immune defense mechanisms, researchers can potentially develop targeted therapies for conditions where dysregulation of the immune response plays a critical role.
Antibody Name:
DEFA6 Antibody (PACO15816)
Antibody SKU:
PACO15816
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human DEFA6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15816(DEFA6 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several α defensin genes appear to be clustered on chromosome 8.
Synonyms:
defensin, α 6, Paneth cell-specific
UniProt Protein Function:
Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
UniProt Protein Details:
NCBI Summary:
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]
